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One of the reasons that could explain this circumstance is that NAM, unlike other NAD + precursors, is also the product of the enzymatic activities of sirtuins, ARTDs, and NADases
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d - u , Correlation between ( d - i ) S1406, ( j - o ) S1859, and ( p - u ) S1900 phosphorylation of CAD and ( d , j , p ) GSK3β phosphorylation at S9, ( e , k , q ) S6 ribosomal protein phosphorylation at S235/S236, ( f , l , r ) OLIG2 protein levels, ( g , m , s ) SOX2 protein levels, ( h , n , t ) ERK1 phosphorylation at T202/Y204, or ( i , o , u ) ERK2 phosphorylation at T185/Y187